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AssigneeAcelot, Inc.
InventorsAmbuj K. Singh, Christian A. Lang
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The present invention provides small molecule drugs and pharmaceutical compositions for the treatment and prevention of diseases related to the formation of certain types of oligomers in a subject. More specifically, the drugs and compositions reduce or prevent the formation of oligomers formed from tau protein, TDP-43, Huntingtin's protein and/or alpha-synuclein. It further provides a method of reducing formation of or disrupting TDP-43, alpha-synuclein, Huntingtin's protein and/or tau protein oligomers in a subject, the method comprising the step of administering to the subject in need thereof a therapeutically effective amount of a pharmaceutical composition.
A method of treating a disease in a subject in need thereof, wherein the disease is caused by deposits of TDP-43 in the brain of the subject and is selected from the group consisting of sporadic amyotrophic lateral sclerosis, frontotemporal dementia, chronic traumatic encephalopathy, progressive supranuclear palsy, corticobasal degeneration, Parkinson's disease, Huntington's disease, limbic-predominant age-related TDP-43 encephalopathy, and motor neuron diseases, the method comprising administering to the subject a therapeutically effective amount of a compound, wherein the compound is one of:
A method of treating a disease in a subject in need thereof, wherein the disease is caused by deposits of TDP-43 in the brain of the subject and is selected from the group consisting of sporadic amyotrophic lateral sclerosis, frontotemporal dementia, chronic traumatic encephalopathy, progressive supranuclear palsy, corticobasal degeneration, Parkinson's disease, Huntington's disease, limbic-predominant age-related TDP-43 encephalopathy, and motor neuron diseases, the method comprising administering to the subject a therapeutically effective amount of a compound selected from the group consisting of
Dependencies are inferred from the claim text.