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US 12,312,622 B2Granted
Method for producing guanidino acetic acid (GAA)
AssigneeEvonik Operations GmbH
InventorsFrank Schneider, Kay Marin, Melanie Nickolaus, Julia Tegethoff, Marleen Oesterhoff
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Abstract
A microorganism is capable of producing guanidinoacetic acid (GAA) that has been improved by using a carbamate kinase. The microorganism with an improved capacity to provide L-arginine as starting material of the GAA biosynthesis by efficient recycling of ornithine improves the production process of GAA. A method for the fermentative production of GAA and a method for the fermentative production of creatine include the incorporation of the microorganism.
Claims15
A microorganism, comprising:
- at least one heterologous gene coding for a protein having a function of a L-arginine:glycine amidinotransferase belonging to E.C. 2.1.4.1;
- at least one heterologous gene coding for a protein having a function of a carbamate kinase belonging to E.C. 2.7.2.2;
- and
- further comprising at least one gene coding for a protein having a function of a NADH-dependent amino acid dehydrogenase belonging to E.C. 1.4.1.
1 more element
Dependencies are inferred from the claim text.