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US 12,312,600 B2Granted
Methods for obtaining induced smooth muscle cells
AssigneeInnovacell AG
InventorsMarco Thurner, Rainer Marksteiner
Life of this patent
Estimating the term…
Abstract
The present invention relates to methods for obtaining induced smooth muscle cells (iSMCs), iSMCs, iSMCs for use in a method of treating a disease or disorder or for use in tissue engineering, and the use of skeletal muscle derived cells for obtaining iSMCs.
Claims7
An in vitro or ex vivo method for obtaining induced smooth muscle cells (iSMCs), the method comprising the steps of:
- (a) obtaining skeletal muscle-derived cells from a subject;
- (b) transdifferentiating skeletal muscle-derived cells by cultivating the cells in a medium containing TGF-beta and heparin to obtain iSMCs,
- wherein the skeletal muscle-derived cells are myogenic progenitor cells (MPCs) characterized by the positive expression of CD56 and desmin, and the negative expression of CD3.
Dependencies are inferred from the claim text.