Methods, compositions, and kits for producing beige adipocytes and treating metabolic disorders
AssigneeMaineHealth
InventorAaron C. Brown
Life of this patent
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Abstract
Provided herein are, inter alia, methods, compositions, and kits for producing adipocyte populations such as beige adipocyte populations. Also included are methods and compositions for increasing the level of adipocyte populations (e.g., beige adipocyte populations) in a subject, as well as methods and compositions for treating subjects who are overweight, obese, or who have diabetes.
Claims17
A method of treating obesity in a subject in need thereof, the method comprising administering to the subject an effective amount of a population of beige adipocytes, or a factor obtained from the population of beige adipocytes, wherein the population of beige adipocytes are produced by contacting a mesenchymal stem cell (MSC) population with an effective amount of
- (i) interleukin 4 (IL-4);
- and
- (ii) a transforming growth factor beta (TGF-β) inhibitor.
A method of treating obesity in a subject in need thereof, the method comprising administering to the subject an effective amount of IL-4 and a TGF-B inhibitor.
A method of increasing the level of a beige adipocyte population in a subject in need thereof, the method comprising administering to the subject an effective amount of IL-4 and a TGF-β inhibitor.
Dependencies are inferred from the claim text.