Methods of AAV therapy
AssigneeBristol-Myers Squibb Company
InventorsUma Kavita, Yanshan Dai, Lisa Salvador
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Abstract
This disclosure provides methods for identifying a subject suitable for an adeno associated vims (AAV) therapy. In some embodiments, the method comprises measuring a titer of an antibody or antigen-binding portion thereof that specifically binds to an AAV (“anti-AAV antibody”) in a biological sample obtained from the subject using an enzyme-linked immunosorbent assay (ELISA).
Claims12
A method of treating a disease in a subject in need of an AAV therapy, comprising administering to the subject the AAV therapy, wherein prior to the AAV therapy the subject is identified as having a low titer of an anti-AAV antibody in a biological sample obtained from the subject, wherein the low titer of the anti-AAV antibody is a titer of which the biological sample emits less than about 700 chemiluminescence units in a chemiluminescence enzyme-linked immunosorbent assay (ELISA).
A method of treating a disease in a subject in need of an AAV therapy, comprising (1) measuring the titer of an anti-AAV antibody in a biological sample obtained from the subject, wherein the biological sample emits less than about 700 chemiluminescence units in a chemiluminescence ELISA and (2) administering to the subject the AAV therapy.
Dependencies are inferred from the claim text.