US 12,312,373 B2 · Cyclopropane skeleton monophosphine ligands, palladium complexes thereof, preparation methods and application

Abstract

The present invention relates to cyclopropane skeleton monophosphine ligands and preparation methods for palladium complexes thereof and an application. Specifically, trans-diaryl substituted cyclopropane skeleton monophosphine ligands are synthesized after trans-1,2-diaryl ethylene undergoing the steps of cyclopropanation reaction, debromination reaction, substitution reaction, and the like. Palladium complexes prepared by coordinating the cyclopropane skeleton monophosphine ligands with a palladium salt show very high activity in catalyzing C—N bond coupling reactions, and have good application prospects.

Claims6

Dependent claims

Cyclopropane skeleton monophosphine ligands, having the following structural formula as I:

where
R1 and R2 are phenyl or substituted phenyl, R3 and R4 are C1-C8 alkyl, and R5 is a hydrogen atom, R1, R2, R3, R4, and R5 being same or different, wherein
in the substituted phenyl, a substituent is one or more of C1-C8 alkyl, C1-C8 alkoxy;
if R1 and R2 are substituted phenyl, the number of substituents is 1 or 2.

1 more element

Dependencies are inferred from the claim text.

Facts

Application

18/783,334Filed 24 Jul 2024 · continuation

Priority

CN 202210095869.326 Jan 2022

Published

US 2024/0376136 A114 Nov 2024

Granted

27 May 2025

Term ends

Not estimatedThe source records don’t support an estimate.

Classification18 codes

C07F 9/5018
Organo-phosphines: cycloaliphatic phosphines
B01J 31/24
Containing coordination complexes: phosphines , i.e. phosphorus bonded to only carbon atoms, or to both carbon and hydrogen atoms, including e.g.…
B01J 31/2404
Phosphines , i.e. phosphorus bonded to only carbon atoms, or to both carbon and hydrogen atoms, including e.g. sp2-hybridised phosphorus…
C07C 209/10
By substitution of halogen atoms: with formation of amino groups bound to carbon atoms of six-membered aromatic rings or from amines having…

Cyclopropane skeleton monophosphine ligands, palladium complexes thereof, preparation methods and application

Life of this patent

Cyclopropane skeleton monophosphine ligands, palladium complexes thereof, preparation methods and application

Life of this patent

Abstract

Claims6