Fluorine-containing substituted benzothiophene compound, and pharmaceutical composition and application thereof

A compound of formula I, or its isomer, prodrug, solvate, hydrate or pharmaceutically acceptable salt thereof,

• wherein,
• R1 and R2 are independently selected from the substituted or unsubstituted group consisting of halogen, amino, hydroxyl, carboxyl, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C8 cycloalkyl, C1-C6 alkoxy, C3-C8 cycloalkoxy, 3-8 membered heterocycloalkyl containing 1 to 3 heteroatoms selected from N, O or S, 3-8 membered heterocycloalkoxy containing 1 to 3 heteroatoms selected from N, O or S, C6-C10 aryl, and 3-10 membered heteroaryl containing 1 to 3 heteroatoms selected from N, O or S;
• or R1 and R2 together with the carbon atoms to which they are attached form a 5-14 membered heterocyclic group;
• the substituted in R1 and R2 refers to be independently substituted by one or more substituents selected from the group consisting of halogen, amino, hydroxy, carboxy, C1-C6 alkyl, C3-C8 cycloalkyl, C1-C6 alkoxy, C3-C8 cycloalkoxy, 3-8 membered heterocyclic group containing 1 to 3 heteroatoms selected from N, O or S, C6-C10 aryl, and 3-10 membered heteroaryl containing 1 to 3 heteroatoms selected from N, O or S;
• X1 and X2 are independently selected from the group consisting of H, D, halogen, unsubstituted or halogen-substituted C1-C6 alkyl, unsubstituted or halogen-substituted C1-C6 alkoxy, and cyano;
• X3 is selected from the group consisting of hydrogen, halogen, hydroxy, C1-C3 alkyl, C1-C3 alkoxy;
• n is an integer selected from 0, 1, 2, 3, 4, 5, 6, 7 or 8;
• Y is selected from the group consisting of —OR3, and —N(X4R4) R5,
• wherein,
• X4 is selected from the group consisting of O, S, and NH;
• R3 is selected from the substituted or unsubstituted group consisting of H, carboxy, sulfonic acid group, phosphoryl group, C1-C6 alkyl, C3-C8 cycloalkyl, C6-C10 aryl, 3-10 membered heteroaryl containing 1 to 3 heteroatoms selected from N, O or S, and 3-8 membered heterocycloalkyl containing 1 to 3 heteroatoms selected from N, O or S;
• R4 and R5 are independently selected from the substituted or unsubstituted group consisting of H, carboxy, sulfonic acid group, phosphoryl group, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C8 cycloalkyl, C1-C6 alkoxy, C3-C8 cycloalkoxy, C6-C10 aryloxy, C6-C10 aryl, 3-8 membered heterocycloalkyl containing 1 to 3 heteroatoms selected from N, O or S, and 3-10 membered heteroaryl containing 1 to 3 heteroatoms selected from N, O or S;
• the substituted in R3, R4 and R5 refers to be independently substituted by one or more substituents selected from the group consisting of halogen, hydroxyl, amino, carboxyl, C1-C6 alkyl, C3-C8 cycloalkyl, C1-C6 alkoxy, C3-C8 cycloalkoxy, 3-8 membered heterocyclic group containing 1 to 3 heteroatoms selected from N, O or S, C6-C10 aryl, and 3-10 membered heteroaryl containing 1 to 3 heteroatoms selected from N, O or S.