Combined bio-artificial liver support system

A combined bio-artificial liver support system, comprising a plurality of branch tubes that are connected in sequence:

• a blood input branch tube, an upstream tail end of which is set as a blood input end, a first plasma separation branch tube comprising at least a first plasma separator, a non-biological purification branch tube comprising at least a plasma perfusion device and a bilirubin adsorber, a biological purification branch tube comprising at least a hepatocyte culture cartridge assembly, and a plasma return branch tube, a downstream tail end of which is set as a blood output end,
• wherein the first plasma separation branch tube comprises:
• the first plasma separator provided with a blood inlet, a plasma outlet, and a blood cell outlet, and a plasma separation pump connected to the plasma outlet through a conduit, the plasma separation branch tube extending downstream from the plasma separation pump, and a first three-way device connected to an end of the plasma separation branch tube, wherein the plasma separation branch tube is directly connected to a first three-way joint of the first three-way device, and the remaining branches extending from the first three-way joint are provided with flow restricting members and coupling members,
• wherein the non-biological purification branch tube comprises:
• a plasma perfusion device provided with a perfusion inlet and a perfusion outlet, a bilirubin adsorber connected to the perfusion outlet through the conduit, a first purification branch extending downstream from the bilirubin adsorber and a second three-way device connected to an end of the first purification branch, wherein the first purification branch is directly communicated with a second three-way joint of the second three-way device, and the remaining branches extending from the second three-way joint are provided with flow restricting members and coupling members,
• wherein the biological purification branch tube comprises:
• an oxygenator provided with an oxygenation outlet, a circulation pump connected to the oxygenation outlet, and a hepatocyte culture cartridge assembly connected to the circulation pump through a circulation branch, a plasma return pump connected to the hepatocyte culture cartridge assembly, and a plasma return branch extending from the plasma return pump to a downstream,
• wherein the plasma return branch comprises at least:
• a blood cell mixer connected to the blood cell outlet and provided with a whole blood outlet, and a bubble monitor connected to the whole blood outlet, the bubble monitor is also connected to the blood output end, and a third three-way device is connected to an upstream end of the plasma return branch tube, the plasma return branch tube is directly connected to a third three-way joint of the third three-way device, an upstream extension branch of the third three-way joint is connected to the first purification branch and the plasma return branch through flow restricting member and coupling members respectively.