Antibodies specific to CD44
AssigneeMultitude Inc.
InventorsShaofei Zhang, Bing Hou, Guangcun Cheng, Shu-Hui Liu, Xun Meng
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Abstract
Antibodies having binding specificity to CD44 v7/8, (a.k.a. CD44 variant 7/8) and antibody-drug conjugates (ADCs) or chimeric antigen receptors comprising such. Also provided herein are uses the anti-CD44 v7/8 antibodies, the ADCs, or immune cells expressing the chimeric antigen receptors for therapeutic and diagnostic purposes.
Claims19
An isolated antibody that binds to human CD44, wherein the antibody comprises a heavy chain variable region (VH) comprising a heavy chain complementary determining region 1 (HC CDR1) of the amino acid sequence of SEQ ID NO:
- 2, a HC CDR2 of the amino acid sequence of SEQ ID NO:
- 3, and a HC CDR3 of the amino acid sequence of SEQ ID NO:
- 4, and a light chain variable region (VL) comprising a light chain CDR1 (LC CDR1) of the amino acid sequence of SEQ ID NO:
- 5, a LC CDR2 of the amino acid sequence of SEQ ID NO:
- 6, and a LC CDR3 of the amino acid sequence of SEQ ID NO:
- 7.
A chimeric antigen receptor, comprising:
- (i) an extracellular domain comprising an antigen binding fragment, (ii) a transmembrane domain, and (iii) one or more intracellular signaling domains, wherein the antigen binding fragment comprises a heavy chain variable region (VH) comprising a heavy chain complementary determining region 1 (HC CDR1) of the amino acid sequence of SEQ ID NO:
- 2, a HC CDR2 of the amino acid sequence of SEQ ID NO:
- 3, and a HC CDR3 of the amino acid sequence of SEQ ID NO:
- 4, and a light chain variable region (VL) comprising a light chain CDR1 (LC CDR1) of the amino acid sequence of SEQ ID NO:
- 5, a LC CDR2 of the amino acid sequence of SEQ ID NO:
- 6, and a LC CDR3 of the amino acid sequence of SEQ ID NO:
- 7.
Dependencies are inferred from the claim text.