Biomarkers and immunogenic compositions for filarial parasites
AssigneesNew York Blood Center, Inc., The United States of America, as represented by the Secretary, Department of Health and Human Services
InventorsSara Lustigman, Thomas B. Nutman, Sasisekhar Bennuru
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Abstract
Disclosed herein are immunogenic compositions for preventing or treating infection with filarial parasites and biomarkers for diagnosing infection with filarial parasites.
Claims6
A method for determining whether a subject has been infected with Onchocerca volvulus, comprising identifying in a specimen from the subject antibodies to O. volvulus filarial proteins Ov16 (SEQ ID NO:63) and OVOC3261 (SEQ ID NO:4), or an immunoreactive fragment thereof, and optionally one or more of OVOC10469 (SEQ ID NO:1), OVOC11950 (SEQ ID NO:2), OVOC10602 (SEQ ID NO:3), OVOC5127 (SEQ ID NO:5), OVOC8491 (SEQ ID NO:6), OVOC6759 (SEQ ID NO:7), OVOC451 (SEQ ID NO:8), OVOC12329 (SEQ ID NO:9), OVOC3337 (SEQ ID NO:10), OVOC10264 (SEQ ID NO:11), OVOC4230 (SEQ ID NO:12), OVOC10384 (SEQ ID NO:13), OVOC8422 (SEQ ID NO:14), OVOC9988 (SEQ ID NO:31), and OVOC6395 (SEQ ID NO:15), or an immunoreactive fragment thereof, wherein presence of antibodies to at least Ov16 and OVOC3261 in the specimen from the subject indicates that the subject has been infected with O. volvulus.
Dependencies are inferred from the claim text.