Methods for treating huntington's disease using a polynucleotide encoding a VTFT isoform of a BPIFB4 protein
AssigneeLgv1 S.R.L.
InventorAnnibale Alessandro Puca
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Abstract
The invention relates inter alia to a protein which is a VTFT isoform of a BPIFB4 protein or a functional fragment thereof for use in the treatment or prophylaxis of a condition selected from neuronal diseases and injuries, said diseases and injuries being associated with mitochondrial dysfunction and/or protein aggregation and/or ameliorated by CXCR4 activation.
Claims8
A method of reducing protein aggregation in Huntington's disease, which comprises administering to a subject in need thereof an effective amount of a polynucleotide encoding a protein which is a VTFT isoform of a BPIFB4 protein, said VTFT isoform comprising a Valine at a position corresponding to position 229 of the amino acid sequence of SEQ ID NO:
- 1, a Threonine at a position corresponding to position 281 of the amino acid sequence of SEQ ID NO:
- 1, a Phenylalanine at a position corresponding to position 488 of the amino acid sequence of SEQ ID NO:
- 1 and a Threonine at a position corresponding to position 494 of the amino acid sequence of SEQ ID NO:
- 1, and wherein the polynucleotide comprises a sequence encoding the protein of SEQ ID NO:1.
A method of reducing protein aggregation in Huntington's disease, which comprises administering to a subject in need thereof an effective amount of a vector comprising a polynucleotide encoding a protein which is a VTFT isoform of a BPIFB4 protein, said VTFT isoform comprising a Valine at a position corresponding to position 229 of the amino acid sequence of SEQ ID NO:
- 1, a Threonine at a position corresponding to position 281 of the amino acid sequence of SEQ ID NO:
- 1, a Phenylalanine at a position corresponding to position 488 of the amino acid sequence of SEQ ID NO:
- 1 and a Threonine at a position corresponding to position 494 of the amino acid sequence of SEQ ID NO:
- 1, and wherein the polynucleotide comprises a sequence encoding the protein of SEQ ID NO:1.
Dependencies are inferred from the claim text.