Chimeric vesiculoviruses and methods of use
AssigneeMayo Foundation for Medical Education and Research
InventorsMitesh J. Borad, Bolni M. Nagalo
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Abstract
The disclosure provides methods and materials for treating cancer. Specifically, the disclosure provides a chimeric vesiculovirus comprising: (a) a first genomic fragment of a first vesiculovirus species; and (b) a second genomic fragment of a second vesiculovirus species different from said first vesiculovirus species; wherein the vesiculovirus species comprising vesicular stomatitis viruses (VSVs) and morreton Virus (MorV). Further disclosed are methods of using chimeric vesiculoviruses as oncolytic agents for treating cancer.
Claims18
A chimeric vesiculovirus comprising:
- (a) a first genomic fragment of a first vesiculovirus species, wherein said first vesiculovirus species is a vesicular stomatitis virus (VSV);
- and
- (b) a second genomic fragment of a second vesiculovirus species different from said first vesiculovirus species, wherein said second vesiculovirus species is a Morreton virus (MORV).
A method for treating a mammal having cancer, wherein said method comprises administering, to said mammal, a chimeric vesiculovirus having oncolytic anti-cancer activity, wherein said chimeric vesiculovirus comprises (a) a first genomic fragment of a first vesiculovirus species, wherein said first vesiculovirus species is a vesicular stomatitis virus (VSV) and (b) a second genomic fragment of a second vesiculovirus species different from said first vesiculovirus species, wherein said second vesiculovirus species is a Morreton virus (MORV).
Dependencies are inferred from the claim text.