US 12,310,830 B2 · Biocompatible membrane composite

Abstract

A biocompatible membrane composite including a cell impermeable layer and a mitigation layer is provided. The cell impermeable layer is impervious to vascular ingrowth and prevents cellular contact from the host. Additionally, the mitigation layer includes solid features. In at least one embodiment, mitigation layer has therein bonded solid features. In some embodiments, the cell impermeable layer and the mitigation layer are intimately bonded or otherwise connected to each other to form a composite layer having a tight/open structure. A reinforcing component may optionally be positioned external to or within the biocompatible membrane composite to provide support to and prevent distortion. The biocompatible membrane composite may be used in or to form a device for encapsulating biological entities, including, but not limited to, pancreatic lineage type cells such as pancreatic progenitors.

Claims28

Dependent claims

A biocompatible membrane composite comprising:

a first layer having pores with a maximum pore size (MPS) less than about 1 micron, wherein the first layer has a first thickness less than 10 microns, and wherein the first layer is cell impermeable;
and
a second layer having solid features, wherein the second layer has a second thickness less than 200 microns, and wherein the second layer allows cellular ingrowth,
wherein a majority of the solid features has a solid feature spacing less than about 50 microns,
wherein the solid features each comprise a representative minor axis, a representative major axis, and a solid feature depth, and
wherein a majority of at least two of the representative minor axis, the representative major axis, and the solid feature depth are greater than about 5 microns.

3 more elements

Dependencies are inferred from the claim text.

Facts

Application

17/595,906Filed 30 May 2020 · us provisional application

Priority

31 May 2019

Published

US 2022/0370184 A124 Nov 2022

Granted

27 May 2025

Term ends

Not estimatedThe source records don’t support an estimate.

Classification18 codes

A61F 2/0077
Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting…:…
A61L 27/16
Macromolecular materials: obtained by reactions only involving carbon-to-carbon unsaturated bonds
A61F 2/022
Prostheses implantable into the body: artificial gland structures using bioreactors
A61L 27/34
Materials for coating prostheses: macromolecular materials

Biocompatible membrane composite

Life of this patent

Biocompatible membrane composite

Life of this patent

Abstract

Claims28