Wearable device such as for glucose measurement

A method of using a wearable device for measuring a target analyte level using coded light illumination of skin, the method comprising:

• encoding an illumination light beam with at least two individually modulated different groups of wavelengths using corresponding different time-varying modulation functions, the illumination light beam including a target component configured for illuminating skin, and including a reference component of the same illumination light beam that does not interact with the skin;
• illuminating skin with the target component of the illumination light beam;
• receiving response light by way of the skin in response to the illuminating, and providing an electrical response signal corresponding to the response light, and receiving the reference component of the illumination light beam that does not interact with the skin, and providing an electrical reference signal corresponding to the reference component of the illumination light beam;
• and
• signal-processing the electrical response signal, including decoding the different time-varying modulation functions by way of the electrical response signal to produce a decoded electrical response signal, and decoding the different time-varying modulation functions by way of the electrical reference signal to provide a decoded electrical reference signal, and adjusting the decoded electrical response signal using the decoded electrical reference signal to provide an adjusted decoded electrical response signal, and using the adjusted decoded electrical response signal to recover a measurement of the target analyte level.

A wearable device that provides non-invasive measurement of a target analyte level using coded light, the wearable device comprising:

• means for concurrently providing an illumination light beam with at least two individually orthogonal-function-modulated different groups of wavelengths respectively using different non-binary time-varying modulation functions, the illumination light beam including a target component configured for illuminating skin and a reference component of the same illumination light beam that does not interact with the skin;
• means for receiving response light from the skin, in response to illumination of the skin using the target component of the illumination light beam, and for providing an electrical response signal indicative of the response light, and for receiving the reference component of the illumination light beam from the optical illuminator, such that the reference component of the illumination light beam does not interact with the skin, for providing a corresponding electrical reference signal;
• and
• means for receiving the electrical response signal and the electrical reference signal and for decoding the time-varying modulation functions from the electrical response signal and the electrical reference signal and for adjusting the decoded electrical response signal using the decoded electrical reference signal to produce an adjusted decoded electrical response signal, and using the adjusted decoded electrical response signal to recover a measurement of the target analyte level.