Biomarkers for detection and treatment assessment of infectious diseases and disorders
AssigneesArizona Board of Regents on behalf of Arizona State University, Mayo Foundation for Medical Education and Research
InventorsDouglas Lake, Haiwei Gu, Thomas Grys, Natalie Mitchell, Paniz Jasbi
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Abstract
The present invention relates to compositions and methods relating to biomarkers that can be used for detection and treatment assessment of infectious diseases or disorders, such as fungal infection, in a subject. The present invention also provides methods of diagnosing infectious diseases or disorders and distinguishing between different types of infectious diseases or disorders (e.g., fungal infection vs bacterial infection). The present invention additionally provides kits that find use in the practice of the methods of the invention.
Claims2
A method of determining if a human subject has an indication of having coccidioidomycosis (Valley fever), the method comprising:
- a) obtaining a plasma sample from a human subject;
- b) measuring the level of 3-phosphoglyceric acid (3-PG) in the plasma sample of the human subject;
- c) determining a mean level of 3-PG in plasma samples acquired from a population of healthy human subjects known not to have coccidioidomycosis;
- d) comparing the measured level of 3-PG in the plasma sample to the mean level of 3-PG in plasma samples acquired from a population of healthy human subjects known not to have coccidioidomycosis;
- and
- e) determining that there is an indication that the human subject has coccidioidomycosis if the measured level of 3-PG in the plasma sample is greater than the mean level of 3-PG in plasma samples acquired from a population of healthy human subjects known not to have coccidioidomycosis.
Dependencies are inferred from the claim text.