Valve switching system for selectively interconnecting components of a bioprocess installation

A valve switching system for selectively interconnecting components of a bioprocess installation, comprising a valve switching cassette and an actuator block, wherein the valve switching cassette comprises a cassette manifold with at least one fluid flow system of ports and fluid lines, which includes primary ports, communicating with primary fluid lines, and secondary ports, communicating with secondary fluid lines, wherein the valve switching cassette comprises an array of switchable valve units for selectively interconnecting the primary fluid lines with the secondary fluid lines via transfer fluid lines, wherein the valve units each comprise a valve seat, wherein the valve switching cassette comprises a valve membrane structure with at least one valve membrane, that can selectively engage the valve seats as to switch the valve units, wherein the actuator block comprises an actuator block body with an actuator for each valve unit,

• wherein that the valve switching cassette comprises a perforated backer plate securing the valve membrane structure to the cassette manifold, that the actuator block comprises a drive membrane structure with at least one drive membrane and a perforated backer plate securing the drive membrane structure to the actuator block body, wherein the perforations of both backer plates each include a pattern of perforation holes, wherein the perforations of both backer plates are at least partly aligned to each other, such that for selectively switching the valve units, an actuator of the actuator block can urge the drive membrane structure through aligned perforation holes of both backer plates into engagement with the valve membrane structure.