G-rich iso-RNA oligomers as aptamers
AssigneeCouncil of Scientific and Industrial Research An Indian Registered Research An Indian Registered Body Incorporated Under the Regn. of Soc. Act (Act Xxi of 1860)
InventorsVaijayanti Anil Kumar, Moneesha Fernandes, Atish Arun Wagh
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Abstract
The present invention relates to G-quadruplex forming iso-RNA oligomers and a process for the preparation thereof. The present invention further relates to a stable, guanine rich 2′-5′-linked iso-RNA selected from 2′-5′-linked iso-RNA. The instant 2′-5′-linked isoRNA oligomer of the thrombin binding aptamer (iso-rTBA) is highly resistant to RNase A and also resistant to other nucleases, including snake venom phosphodiesterase (SVPD) and forms a thermally stable functional G-quadruplex.
Claims8
G-quadruplex forming iso-RNA oligomers comprising a 2′-5′-linked iso-RNA sequence;
- wherein the G-quadruplex forming iso-RNA oligomers are configured to bind thrombin, wherein the 2′-5′-linked isoRNA sequence is a thrombin-binding aptamer (iso-rTBA) comprising SEQ ID NO:1.
Dependencies are inferred from the claim text.