Compositions and methods for treating cancer

A double stranded RNA interference (RNAi) agent comprising:

• a combination of (i) a first double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of a CD320 gene wherein the first dsRNA comprises a sense strand and an antisense strand forming a duplex, and (ii) a second dsRNA for inhibiting the expression of a LRP2 gene wherein the second dsRNA comprises a sense strand and an antisense strand forming a duplex, and wherein the sense strand of the first dsRNA is at least substantially complementary to the antisense strand of the first dsRNA and the sense strand of the second dsRNA is at least substantially complementary to the antisense strand of the second dsRNA wherein the antisense strand of (i) the first dsRNA is selected from
• (SEQ ID NO:
• 17)
• CAGUUGCGCAGUUUCUUGUCAGUUCdTdT;
• (SEQ ID NO 18)
• CAGUUGCGCAGUUUCUUGUCAGUUCdT*dT;
• (SEQ ID NO 64)
• AAGAGCUCAGGUCUCUGAGGGdTdT;
• and
• (SEQ ID NO 65)
• AAGAGCUCAGGUCUCUGAGGGdT*dT;
• and
• the antisense strand of (ii) the second dsRNA is selected from
• (SEQ ID NO:
• 417)
• UUUGAUAGCACCAAACCUAGAGCCCdTdT;
• (SEQ ID NO:
• 418)
• UUUGAUAGCACCAAACCUAGAGCCCdT*dT;
• (SEQ ID NO:
• 448)
• UUUGCAAUGACUCUCCUAUCAGUCCdTdT;
• and
• (SEQ ID NO:
• 449)
• UUUGCAAUGACUCUCCUAUCAGUCCdT*dT;
• wherein * is a phosphorothioate linkage.