Separation and collection device for cells and biomolecules, and testing system
AssigneeBgi Shenzhen
InventorsJing Zhao, Yuan Jiang, Wen-Wei Zhang, Xia Zhao, Ao Chen
Life of this patent
Estimating the term…
Abstract
A separation and collection device for cells and biomolecules includes an annular tube and several magnetic beads configured to identify and bind with different cells or molecules in the biological sample. The annular tube defines a through hole for the biological sample to exit. Sizes of different groups of magnetic beads are different. An aperture size of a through hole is changeable such that the plurality of groups of magnetic beads can flow through the through hole in a certain order. A testing system including the separation and collection device is further disclosed.
Claims17
A separation and collection device for cells and biomolecules, comprising:
- a first separation device comprising:
- an annular tube configured for containing a biological sample, the annular tube defining a through hole for the biological sample to flow out;
- and
- a plurality of groups of magnetic beads configured to identify and bind with different cells or molecules in the biological sample, a size of each of the plurality of groups of magnetic beads being different;
- wherein an aperture size of the through hole is changeable such that the plurality of groups of magnetic beads can flow through the through hole in a certain order;
- and
- the annular tube comprises an inner tube and an outer tube sleeved on the inner tube, a first bead hole is defined on the periphery wall of the inner tube, and a second bead hole is defined on a periphery wall of the outer tube, the second bead hole corresponds in position to the first bead hole, the second bead hole communicates with the first bead hole to form the through hole, and the outer tube and the inner tube are rotatable relative to each other.
A testing system comprising:
- a separation and collection device for cells and biomolecules, comprising:
- a first separation device comprising:
- an annular tube configured for containing a biological sample, the annular tube defining a through hole for the biological sample to flow out, and
- a plurality of groups of magnetic beads configured to identify and bind with different cells or molecules in the biological sample, a size of each of the plurality of groups of magnetic beads being different;
- a microfluidic system combined with the separation and collection device;
- and
- a gene sequencing system combined with the microfluidic system;
- wherein an aperture size of the through hole is changeable such that the plurality of groups of magnetic beads can flow through the through hole in a certain order;
- and
- the annular tube comprises an inner tube and an outer tube sleeved on the inner tube, a first bead hole is defined on the periphery wall of the inner tube, a second bead hole is defined on a periphery wall of the outer tube, the second bead hole corresponds in position to the first bead hole, the second bead hole communicates with the first bead hole to form the through hole, and the outer tube and the inner tube are rotatable relative to each other.
Dependencies are inferred from the claim text.