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US 12,304,944 B2Granted
Methods and compositions for modified factor IX fusion proteins
AssigneeThe University of North Carolina at Chapel Hill
InventorTal Kafri
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Abstract
The present invention provides Factor IX fusion proteins with higher specific activity and a longer useful clotting function relative to wild type or non-modified Factor IX protein.
Claims5
A PKR-deficient packaging cell that generates an integration-competent lentiviral vector that comprises an expression cassette in opposite orientation to long terminal repeats (LTRs) of the vector genome and a self-inactivating 3′ U3.
Dependencies are inferred from the claim text.