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US 12,304,930 B2Granted
Prefusion-stabilized hMPV F proteins
AssigneeBoard of Regents, The University of Texas System
InventorsJason McLellan, Ching-Lin Hsieh, Scott Rush, Nianshuang Wang
Life of this patent
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Abstract
Provided herein are engineered hMPV F proteins. In some aspects, the engineered F proteins exhibit enhanced conformational stability and/or antigenicity. Methods are also provided for use of the engineered F proteins as diagnostics, in screening platforms, and/or in vaccine compositions.
Claims18
A nucleic acid molecule comprising a nucleotide sequence that encodes an amino acid sequence of an engineered protein comprising a metapneumovirus (MPV) F protein ectodomain having at least 90% identity to amino acids 19-489 of any one of SEQ ID NOs:
- 4-7, said engineered protein comprising a mutation at positions A140, A147 and A/D185, relative to the sequence of any one of SEQ ID NOs:
- 4-7, wherein the nucleic acid molecules is an mRNA molecule.
Dependencies are inferred from the claim text.