Pleuromutilin derivative containing a thiazolo[5,4-c]pyridine side chain, and a preparation method and application thereof
AssigneeShaanxi University of Science and Technology
InventorsChengyuan Liang, Yanzi Wang, Bingxing Zhang, Wen Wang, Yunfei Zhang
Life of this patent
Estimating the term…
Abstract
A compound of formula I, a pharmaceutically acceptable salt thereof, or a solvent compound, an enantiomer, a diastereomer or a tautomer of the compound or a pharmaceutically acceptable salt thereof is disclosed, wherein R is a phenyl substituted with an electron withdrawing group or a phenyl substituted with an electron donating group. The pleuromutilin derivative containing a thiazolo[5,4-C]pyridine side chain in the present invention exhibits good in vitro antibacterial activity and improves the problem of poor solubility of pleuromutilin derivatives.
Claims11
A compound of formula I, a pharmaceutically acceptable salt, or a tautomer thereof:
- wherein R is a phenyl group substituted with an electron withdrawing group or a phenyl group substituted with an electron donating group.
Dependencies are inferred from the claim text.