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US 12,304,900 B2Granted
Islet cell manufacturing compositions and methods of use
AssigneeVertex Pharmaceuticals Incorporated
InventorsAustin Thiel, Jihad Yasin, Evrett Thompson, Felicia J. Pagliuca
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Abstract
Disclosed herein are compositions and methods useful for manufacturing SC-β cell, and isolated populations of SC-β cells for use in various applications, such as cell therapy.
Claims24
A composition comprising a population of PDX1-negative primitive gut tube cells and a BMP signaling pathway inhibitor, wherein the BMP signaling pathway inhibitor is a compound of Formula A,
Dependencies are inferred from the claim text.