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US 12,304,892 B2Granted
Method for preparation of Carsalam
AssigneeLonza Guangzhou Pharmaceutical Ltd.
InventorsXingbang Lin, Ji Zhou
Life of this patent
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Abstract
The invention discloses a method for preparation of Carsalam by a reaction of salicylamide with diethyl carbonate in the presence of an alkali ethoxide.
Claims16
A method for the preparation of compound of formula (3)
- with two subsequent reactions REAC1 and REAC2;
- in the first reaction REAC1 salicylamide is reacted with diethylcarbonate in the presence of an alkali ethoxide to provide compound of formula (3-X)
- in the second reaction REAC2 compound of formula (3-X) obtained from REAC1 is reacted with a Bronsted acid to provide compound of formula (3);
- X is Na or K;
- the alkali ethoxide is NaOEt or KOEt.
2 more elements
Dependencies are inferred from the claim text.