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US 12,303,845 B2Granted
Method for crystallization of active pharmaceutical ingredients
AssigneeNanoform Finland Oyj
InventorsMartti Kaasalainen, Tatiana Danilova, Niklas Sandler, Eric Kissi, Nikolay Houbenov
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Abstract
The disclosure relates to methods for crystallization of active pharmaceutical ingredients (APIs), wherein the crystallization and crystal growth is controlled. According to the method solid amorphous nanosized API and an aqueous solution comprising one or more polymers and/or copolymers are contacted so as to form a suspension comprising nanosized API in crystalline form.
Claims19
A method for crystallization of active pharmaceutical ingredient (API), the method comprising:
- providing amorphous nanosized API;
- providing an aqueous solution comprising one or more polymers and/or copolymers;
- and
- contacting the amorphous nanosized API and the aqueous solution comprising the one or more polymers and/or copolymers to form an admixture wherein content of the amorphous nanosized API in the admixture is higher than solubility of the amorphous nanosized API in the aqueous solution comprising the one or more polymers and/or copolymers,
- thereby obtaining a suspension comprising nanosized API in crystalline form.
2 more elements
Dependencies are inferred from the claim text.