Use of self-assembled alkylsilane coatings for drug delivery applications
AssigneeUniversity of Pittsburgh—Of the Commonwealth System of Higher Education
InventorsElia Beniash, Avinash Patil
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Abstract
The invention relates to self-assembled organosilane- and small molecule drug-containing coatings for resorbable medical implant devices. The coatings can be prepared from precursor compositions containing an organosilane and a small molecule drug, and can be applied to substrates. Prior to applying the coatings, the surfaces of the substrates can be pretreated. The coatings can be functionalized with a binding compound that is coupled with an active component. The coatings can be applied using various techniques and apparatus, more particularly, by a deep-coating process conducted at ambient conditions.
Claims7
A medical implant device, comprising:
- a substrate composed of a material selected from the group consisting of magnesium and magnesium alloy having an outer surface;
- a thin film, self-assembled coating having a laminar structure comprising multilayers, applied to the outer surface of the substrate, the self-assembled coating comprising:
- a coating composition, comprising:
- an organic small molecule drug;
- and
- a hybrid amphiphilic alkylsilane consisting of a hydrophobic aliphatic tail with a C4 to C20 aliphatic backbone and a hydrophilic silane head reactive with the substrate, comprising:
- a cross-linking agent combined with the alkylsilane;
- an aminosilane binding compound combined with the self-assembled coating;
- and
- an active component coupled to the aminosilane binding compound,
- wherein the self-assembled coating reduces degradation rate of the substrate, and
- wherein a release concentration of the organic small molecule drug from the medical implant device increases incrementally over time.
Dependencies are inferred from the claim text.