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US 12,303,618 B2Granted
Oxygen-generating cryogels
AssigneeNortheastern University
InventorsAdnan Memic, Sidi A. Bencherif, Michail Sitkovsky, Thibault Colombani, Stephen Hatfield
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Abstract
Disclosed are nanocomposite oxygen-generating cryogels and their uses in reducing hypoxia in a biological tissue, such as a tumor. Methods of treating cancer with the disclosed cryogels are also provided.
Claims21
A method of reducing hypoxia in a biological tissue, comprising administering to the biological tissue an oxygen-generating cryogel, wherein the administration is by injection, catheter, or surgery;
- and the cryogel comprises:
- i) a lyoprotectant;
- ii) a peroxide, an oxide or a percarbonate;
- iii) a catalase, wherein the catalase is acrylate-PEG-catalase;
- and
- iv) polymerized hyaluronic acid.
3 more elements
Dependencies are inferred from the claim text.