Anti-LAM and anti-PIM6/LAM monoclonal antibodies for diagnosis and treatment of Mycobacterium tuberculosis infections
AssigneeRutgers, The State University of New Jersey
InventorsAbraham Pinter, Alok K. Choudhary, Deendayal Patel
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Abstract
The present invention broadly provides different compositions, kits, vectors, and methods including monoclonal antibodies directed to epitopes found within lipoarabinomannan (LAM) and phosphatidyl-myo-inositol mannoside 6 (PIM6) for the diagnosis and treatment of Mycobacterium tuberculosis infections.
Claims11
A monoclonal anti-PIM6/LAM antibody, or an antigen-binding portion thereof, that specifically binds to an epitope present in lipoarabinomannan (LAM) and phosphatidyl-myo-inositol mannoside 6 (PIM6), the epitope comprising at least one polymannose structure, wherein the anti-PIM6/LAM antibody comprises a CDR1 light chain variable region having at least 80% identity with SEQ ID NO:
- 13 or antigenic fragments thereof, a CDR2 light chain variable region having at least 80% identity with SEQ ID NO:
- 14 or antigenic fragments thereof, a CDR3 light chain variable region having at least 80% identity with SEQ ID NO:
- 15 or antigenic fragments thereof, a CDR1 heavy chain variable region having at least 80% identity with SEQ ID NO:
- 16 or antigenic fragments thereof, a CDR2 heavy chain variable region having at least 80% identity with SEQ ID NO:
- 17 or antigenic fragments thereof, and a CDR3 heavy chain variable region having at least 80% identity with SEQ ID NO:
- 18 or antigenic fragments thereof, having a modified heavy chain variable region and a modified light chain variable region.
Dependencies are inferred from the claim text.