Peptides for treatment and prevention of diabetes and associated disorders

A method of treating diabetes and associated disorders selected from the group consisting of type I diabetes, type II diabetes, insulin resistance, diabetic retinopathy, diabetic neuropathy, diabetic nephropathy, hyperglycemia, hyperinsulinaemia and Bardet Biedl syndrome comprising the administration of a peptide to a subject in need of treatment, wherein:

• the peptide does not simultaneously comprise methionine, proline and arginine residues;
• the peptide adopts a secondary structure which is a helix or an alpha helix;
• the peptide has a length from 12 to 60 amino acids;
• and
• wherein the peptide sequence comprises one of the following sequences:
• (SEQ ID NO:
• 27)
• VECTXXEKXVLAX;
• (SEQ ID NO:
• 28)
• VECTXXEKXVLAXLDKXXFLTQLHS;
• wherein the residues which are bold and underlined X carry a stapling and is any amino acid derivative suitable for stapling;
• and
• wherein X is any amino acid except M, P and R.