Antimicrobial compositions and methods of use thereof

A pharmaceutical composition for treating a gram positive or gram negative bacterial infection, comprising:

• (1) an antimicrobial peptide comprising an antimicrobial domain comprising the amino acid sequence of SEQ ID NO:
• 3 bound at the N- or C-terminus to a cell penetrating peptide (CPP) domain;
• and (2) a pharmaceutically acceptable carrier;
• wherein the CPP is one selected from the group consisting of HIV TAT49-.s7 peptide, HIV TAT 48-60 peptide, low molecular weight protamine (LMWP) peptide;
• Pep-1;
• Antp43-58 peptide, MPG (HIV Gp41-SV40 NLS), SAP, MPG R9, MAP, K-FGF, Penetratin, Buforin II, Transportan, Ku70, Prion, pVEC, Pep-1-K, Pep-7, HN-1, TP10, and CP26.