Cytotoxic and anti-mitotic compounds, and methods of using the same
AssigneeZymeworks BC Inc.
InventorsGeoffrey C. Winters, Alexander Laurence Mandel, James R. Rich, Bradley John Hedberg, Tom Han Hsiao Hsieh, Elyse Marie Josée Bourque, John Babcook
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Abstract
Compounds having cytotoxic and/or anti-mitotic activity are disclosed. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed. Also disclosed are compositions having the structure: (T)-(L)-(D), wherein (T) is a targeting moiety, (L) is an optional linker, and (D) is a compound having cytotoxic and/or anti-mitotic activity.
Claims24
An antibody-drug conjugate comprising a targeting moiety (T), a linker (L) and a drug moiety (D), wherein the targeting moiety (T) is an antibody or antigen-binding antibody fragment and the drug moiety (D) is a compound of Formula (Ib):
- wherein:
- R16 is selected from the group consisting of H and C1-6 alkyl;
- R17 is selected from the group consisting of H and C1-6 alkyl;
- R18 is C1-6 alkyl;
- R26 is selected from the group consisting of optionally substituted alkyl and optionally substituted aryl, and
- R27 is
- and
- wherein a C-terminus of the drug moiety (D) forms the point of attachment to the targeting moiety (T) via the linker (L).
Dependencies are inferred from the claim text.