RNA viruses for immunovirotherapy
AssigneeDeutsches Krebsforschung-Szentrum, Ruprecht-Karls-Universitat Heidelberg
InventorsChristine Engeland, Guy Ungerechts, Sascha Bossow
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Abstract
The present invention relates to a recombinant virus of the family Paramyxoviridae, comprising at least one expressible polynucleotide encoding a secreted activator of the immune response, to a polynucleotide encoding the same, and to a kit comprising the same. Moreover, the present invention relates to a method for treating cancer in a subject afflicted with cancer, comprising contacting said subject with a recombinant virus of the family Paramyxoviridae of the invention, and thereby, treating cancer in a subject afflicted with cancer.
Claims18
A polynucleotide encoding a recombinant measles virus, the polynucleotide comprising at least one expressible polynucleotide encoding a secreted activator of the immune response, wherein the secreted activator of the immune response is encoded by the nucleotide sequence depicted in SEQ ID NOs:
- 2, and/or 4, and wherein the recombinant measles virus is derived from the Edmonston B strain of measles virus.
Dependencies are inferred from the claim text.