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US 12,303,502 B2Granted
Oral liquid composition comprising ivacaftor
AssigneeKinedexe UK Limited
InventorsVardhaman Chandrakant Bafna, Mahesh Mohanrao Bhadgale, Mokshada Milind Vable, Sweety Rajbahadur Singh
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Abstract
The present invention provides a stable oral liquid solution composition comprising ivacaftor or a pharmaceutically acceptable salt or solvate thereof and a solvent system selected from the group consisting of Polyethylene Glycols 400 and/or Hydrogenated Vegetable Oil used individually or in combination thereof. The invention also provides a method for treating or lessening the severity of cystic fibrosis is provided.
Claims25
A liquid composition comprising:
- (a) a solvent system comprising a polyethylene glycol and a hydrogenated vegetable oil;
- and
- (b) a therapeutically effective amount of ivacaftor of Formula I:
- or a pharmaceutically acceptable salt thereof;
- wherein the liquid composition is formulated for oral administration.
2 more elements
A liquid composition comprising:
- (a) a solvent system comprising polyethylene glycol 400 and hydrogenated castor oil;
- (b) a therapeutically effective amount of ivacaftor of Formula I:
- or a pharmaceutically acceptable salt thereof;
- (c) a solubilizing agent which is sodium lauryl sulfate;
- (d) an antimicrobial preservative which is methyl parahydroxybenzoate (methylparaben);
- and
- (e) an antioxidant which is butylated hydroxyanisole (BHA);
- wherein the liquid composition is formulated for oral administration.
5 more elements
Dependencies are inferred from the claim text.