Histotripsy for thrombolysis

An ultrasound therapy system, comprising:

• a motorized positioning system;
• an ultrasound transducer array coupled to the motorized positioning system;
• a generator configured to couple to the ultrasound transducer array, the generator and ultrasound transducer array being configured to generate cavitation in a target tissue of a subject for controlled mechanical fractionation of the target tissue;
• at least one processor configured to couple to the motorized positioning system and the generator, the at least one processor being configured to control the motorized positioning system and the generator to provide histotripsy therapy to the subject by:
• outputting an ultrasound pulse sequence from the ultrasound transducer array resulting in cavitation forming a bubble cloud;
• detecting a location of the bubble cloud;
• actuating the motorized positioning system and ultrasound transducer array such that the bubble cloud is spatially positioned within the target tissue in response to the location of the bubble cloud;
• controlling the ultrasound transducer array to monitor backscatter from the bubble cloud;
• and
• controlling the generator to adjust one or more parameters of the ultrasound pulse sequence based on the monitored backscatter from the bubble cloud.