US 12,298,230 B2Granted

Detection method

AssigneeBiosurfit, S.A.

InventorsJosé Pedro Santos Manso Côrte-Real, José Miguel Silva Do Carmo Nogueira, André Miguel Alves Farinha, Alberto Eduardo Artilheiro Ferreira, Tiago Filipe Pinto Silva, Mauro Miguel Melo Ribeiro, Filipe Da Conceição Fernandes Thomaz, João Manuel De Oliveira Garcia Da Fonseca

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Abstract

A detection system including a detection device and an assay device. The detection device includes a space for receiving an assay device, a drive arrangement engaging the assay device to rotate the assay device, a light source arranged to direct light towards the assay device, and a diffuser arranged to diffuse light from the light source. The diffuser is arranged between the light source and the space. The detection device includes a light receiver arranged to receive light from the light source that has passed through the assay device.

Claims15

Dependent claims

A method of determining an effect of a liquid sample on light, the method comprising:

rotating an assay device comprising one or more chambers for containing the liquid sample;
directing light from a light source to the rotating assay device such that the light passes through the one or more chambers as each of the one or more chambers is in a respective predetermined configuration relative to the light source and a light receiver, and wherein the light source and the light receiver are arranged on the same side of the rotating assay device;
receiving, at the light receiver, light from the light source that has passed through the one or more chambers within the rotating assay device for at least one complete rotation of the assay device;
determining a set of light intensity measurements for each complete rotation of the assay device;
determining measurements of light intensity within each set of light intensity measurements that were obtained when the light passed through the one or more chambers;
determining the number of measurements that meet a light intensity condition in one of the sets of measurements;
changing the light intensity condition for sets of measurements for subsequent complete rotations based on the number of measurements that met the light intensity condition;
and
determining, using the measurements of light intensity that were obtained when the light passed through the one or more chambers, the effect of the liquid sample on the light from the light source.

6 more elements

A detection system comprising:

an assay device having one or more chambers for containing a liquid sample;
a drive arrangement engaging the assay device to rotate the assay device;
one or more light sources each arranged to emit light towards a corresponding one of the one or more chambers within the assay device;
a light receiver corresponding to each of the one or more light sources, each light receiver arranged to receive light from the corresponding one of the one or more chambers within the assay device;
and
one or more processors programmed to:
cause the drive arrangement to rotate the assay device at least one complete rotation;
cause the one or more light sources to emit light towards the rotating assay device;
receive signals from each light receiver;
determine a set of light intensity measurements for each complete rotation of the assay device;
determine measurements of light intensity within each set of light intensity measurements that were obtained when the light passed through the one or more chambers;
determining the number of measurements that meet a light intensity condition in one of the sets of measurements;
changing the light intensity condition for sets of measurements for subsequent complete rotations based on the number of measurements that met the light intensity condition;
and
determine, using the measurements of light intensity that were obtained when the light passed through the one or more chambers, the effect of the liquid sample on the light from the light source.

12 more elements

Dependencies are inferred from the claim text.

Facts

Application: 16/644,770Filed 4 Sep 2018
Priority: PT 110277 J5 Sep 2017
Published: US 2021/0063303 A14 Mar 2021
Granted: 13 May 2025
Term ends: Not estimatedThe source records don’t support an estimate.

Classification13 codes

G01N 21/272
Using photo-electric detection ; circuits for computing concentration: for following a reaction, e.g. for determining photometrically a reaction rate
G01N 21/0303
Cuvette constructions: optical path conditioning in cuvettes, e.g. windows; adapted optical elements or systems; path modifying or adjustment
G01N 21/07
Cuvette constructions: centrifugal type cuvettes
G01N 21/75
Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light: systems…