Methods for diagnosing and treating eosinophilic gastritis

A method for treating eosinophilic gastritis (EG) or eosinophilic gastroenteritis (EGE) in a subject in need thereof, the method comprising

• a) determining amounts of CCL26 protein, IL-5 protein, and TSLP protein, or peptide or polypeptide fragments thereof in a serum fraction of a blood sample obtained from the subject at an initial time point;
• b) detecting an elevated amount of two or more of CCL26, IL-5, and TSLP proteins, or peptide or polypeptide fragments thereof, in the serum fraction, relative to a predetermined control value;
• c) diagnosing the subject as having EG or EGE;
• and
• d) administering to the subject diagnosed with EG or EGE i) a therapeutic agent selected from the group consisting of a glucocorticoid, a leukotriene inhibitor, azathioprine, an anti-histamine, a mast-cell stabilizer, a macrolide antibiotic, and anti-cytokine therapy, or ii) a dietary therapy which alleviates one or more symptoms or complications of EG or EGE selected from a restricted diet, an elemental diet, and an elimination diet.