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US 12,297,468 B2Granted
pAPN mutant and composition for site-directed modification of pAPN gene and application thereof
AssigneeAgsino Gensources Co., Ltd.
InventorsKui Li, Yulian Mu, Lei Huang
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Abstract
The present invention provides a pAPN mutant and a composition for site-directed modification of pAPN gene and application thereof, involving the field of gene editing technology. The mutated pAPN mutant with an alanine at position 734 can maintain its normal expression, while reducing the ability of a host expressing the pAPN mutant to specifically bind to TGEV, which has important scientific and practical significance in pig disease resistance breeding.
Claims2
A pAPN mutant having an alanine at position 734, wherein the amino acid sequence of the pAPN mutant is forth in SEQ ID NO:
- 1.
Dependencies are inferred from the claim text.