Gene expression elements and systems and use thereof
AssigneeGeneneer Ltd.
InventorKinneret Shefer
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Abstract
The present invention provides a versatile platform system for regulating gene expression in cells of eukaryotic organisms, including plants, algae and fungi, and mammals. A platform system of the invention includes an expression control element and expression system comprising the same. Expression control elements according to the invention can be inserted into a variety of cell types having the capability of alternative splicing and can be regulated by a polyamine or polyamine analogues. Host cells comprising the expression control elements of the invention are typically grown in a cell or tissue culture, or form part of a living plant, algae, or fungi.
Claims19
An isolated expression control element (ECE), comprising a polyamine or polyamine analog responsive nucleic acid sequence having the nucleic acid sequence as set forth in SEQ ID NO:
- 3 flanked at its 5′ end and 3′ end by splice sites, further comprising at least one intron sequence flanking each of the splice sites, wherein the at least one intron length is from 10 nucleotides to 150 nucleotides.
Dependencies are inferred from the claim text.