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AssigneeBoston Scientific Scimed, Inc.
InventorsJoseph T. Delaney, Jr., Kolbein K. Kolste, Tatyana Dyndikova
Estimating the term…
In some aspects, the present disclosure pertains to a polymer that comprises a plurality of polymeric arms, wherein a first portion of the polymeric arms each comprises a reactive end group and wherein a second portion of the polymeric arms each comprises a radiopaque aromatic moiety comprising a monocyclic or multicyclic aromatic structure having a plurality of radiopaque functional groups and a plurality of hydrophilic functional groups. In some aspects, the present disclosure pertains to systems comprising (a) a first composition comprising such a radiopaque polymer and (b) a second composition comprising a multifunctional compound that comprises reactive functional groups that are reactive with the reactive end group. In some aspects, the present disclosure pertains to crosslinked reaction products of (a) such a radiopaque polymer and (b) a multifunctional compound that comprises reactive functional groups that are reactive with the reactive end group.
A multi-arm polymer comprising a plurality of polymeric arms that comprise one or more hydrophilic monomers, wherein a first portion of the polymeric arms comprise a reactive imide ester end group comprising a succinimidyl glutarate group and wherein a remaining second portion of the polymeric arms comprise a radiopaque aromatic moiety comprising a monocyclic or multicyclic aromatic structure having a plurality of radiopaque halide groups and a plurality of hydrophilic functional groups that comprise hydrophilic amine groups, the radiopaque aromatic moiety linked to the remaining second portion of the polymer arms through an amide group, wherein the multi-arm polymer is formed by a process wherein between 25% and 75% of the succinimidyl groups of a succinimidyl-glutarate-substituted multi-arm polymer are replaced by radiopaque aromatic moieties.
Dependencies are inferred from the claim text.