Amphiphilic compound, and medical resin composition and pharmaceutical additive using the same
AssigneeNippon Shokubai Co., Ltd.
InventorsMasato Imase, Akane Sato
Life of this patent
Estimating the term…
Abstract
Provided is means capable of reducing the adsorptivity to plastics while suppressing a decrease in intracellular uptake efficiency in an amphiphilic compound that can be applied to long-term blood-retaining liposomes or the like as a drug carrier. The above problem can be solved by an amphiphilic compound comprising a moiety (I) including a constitutional unit (A) derived from a monomer (a) having two or more hydroxyl groups and having 2 to 10 carbon atoms constituting the side chain among the carbon atoms of the constitutional unit, and a hydrocarbon group having 8 or more carbon atoms.
Claims17
An amphiphilic compound comprising:
- a moiety (I) including a constitutional unit (A);
- and
- a hydrocarbon group having 8 or more carbon atoms,
- wherein the constitutional unit (A) includes a constitutional unit represented by chemical formula (1):
- wherein R1 represents a hydrogen atom or a methyl group, and X represents —C(═O)—O—, —C(═O)—NH—, —O—, —CH2O—, or —CH2CH2O—,
- the hydrocarbon group having 8 or more carbon atoms is bonded to the moiety (I) via a divalent bonding group containing a group selected from the group consisting of —S—, —S—C(═S)—, —S—C(═S)—S—, —S—C(═S)—N(—Ra)—, —S—C(═S)—O—, —S—Rb—C(═O)—O—, —S—Rb—C(═O)—N(—Ra)—, —S—Rb—O—, —S—Rb—O—C(═O)—, and —N(—Ra)—C(═O)—, wherein Ra is a hydrogen atom or a hydrocarbon group having 1 to 30 carbon atoms, and Rb is a hydrocarbon group having 1 to 30 carbon atoms.
Dependencies are inferred from the claim text.