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US 12,297,294 B2Granted
Cortistatin analogues for the treatment of inflammatory and/or immune diseases
AssigneeBcn Peptides, S.A.
InventorsBerta Ponsati Obiols, Jimena Fernández Carneado, Josep Farrera-Sinfreu, Antonio Parente Dueña
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Abstract
The invention relates to cortistatin analogues and their uses. The compounds of the invention are peptide ligands with potential application in the diagnosis, prevention or therapy of those pathologies where receptors capable of binding to cortistatin, specific or shared with other molecules such as somatostatin and/or ghrelin (GHSR), are expressed, being in addition more stable in serum than cortistatin.
Claims7
A cortistatin analogue compound selected from the group consisting of:
- (SEQ ID NO:
- 4)
- H-L-Ala-Gly-c[L-Cys-L-Lys-L-Asn-L-Phe-L-Dfp-D-Trp-
- L-Lys-L-Thr-L-Phe-L-Thr-L-Ser-L-Cys]-OH,
- (Octanoyl-SEQ ID NO:
- 8)
- Octanoyl-L-Pro-c[L-Cys-L-Lys-L-Asn-L-Msa-L-Phe-D-
- Trp-L-Lys-L-Thr-L-Phe-L-Thr-L-Ser-L-Cys]-L-Lys-OH,
- (Octanoyl-SEQ ID NO:
- 14)
- Octanoyl-L-Pro-c[L-Cys-L-Lys-L-Asn-L-Msa-L-Phe-D-
- Trp-L-Lys-L-Thr-L-Phe-L-Thr-L-Ser-L-Cys]-OH,
- its stereoisomers, mixtures thereof or its pharmaceutically acceptable salts thereof, and wherein the compound has cortistatin anti-inflammatory and immunoregulatory activity.
10 more elements
Dependencies are inferred from the claim text.