Aspergillus antigen chimeric receptors and use thereof
AssigneeBoard of Regents, The University of Texas System
InventorsPappanaicken Kumar, Thiago Aparecido Da Silva, Paul J. Hauser
Life of this patent
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Abstract
Provided herein is an antibody as well as chimeric antigen receptor (CAR) to the Aspergillus antigen p60-binding domain. Further provided herein are immune cells expressing the CARs as well as methods of their use in the treatment of fungal infections and cancer.
Claims20
An isolated monoclonal antibody, wherein the antibody specifically binds to Aspergillus antigen p60 and comprises:
- (a) a first VH CDR encoded by SEQ ID NO:
- 7;
- (b) a second VH CDR encoded by SEQ ID NO:
- 8;
- (c) a third VH CDR encoded by SEQ ID NO:
- 9;
- (d) a first VL CDR encoded by SEQ ID NO:
- 2;
- (e) a second VL CDR encoded by SEQ ID NO:
- 3;
- and
- (f) a third VL CDR encoded by SEQ ID NO:
- 4.
A recombinant polypeptide comprising an antibody VH domain comprising CDRs 1-3 of the VH domain of AF269-5 (SEQ ID NOs:
- 7, 8, and 9) and an antibody VL domain comprising CDRs 1-3 of the VL domain of AF269-5 (SEQ ID NOs:
- 2, 3, and 4).
A chimeric antigen receptor (CAR) comprising an Aspergillus antigen p60-binding domain comprising:
- (a) a first VH CDR encoded by SEQ ID NO:
- 7;
- (b) a second VH CDR encoded by SEQ ID NO:
- 8;
- (c) a third VH CDR encoded by SEQ ID NO:
- 9;
- (d) a first VL CDR encoded by SEQ ID NO:
- 2;
- (e) a second VL CDR encoded by SEQ ID NO:
- 3;
- and
- (f) a third VL CDR encoded by SEQ ID NO:
- 4.
Dependencies are inferred from the claim text.