Shape-responsive nanostructures
AssigneeCarnegie Mellon University
InventorsRebecca Taylor, Sriram Kumar, Dilhara R. Jayarathna
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Abstract
Provided herein are single-stranded tile (SST) structures prepared from and comprising single-stranded γPNA (ss-γPNA) strands, along with methods of making an SST structure from single-stranded γPNA (ss-γPNA) strands.
Claims23
A single-stranded tile (SST) structure, comprising a complex of one or more single-stranded gamma peptide-nucleic acid (ss-γPNA) species, the ss-γPNAs of the SST structure comprising one or more pairs of complementary binding domains arranged on the one or more ss-γPNA species to produce a periodic arrangement of at least 3 molecules of the one or more ss-γPNA species by hybridization of the complementary nucleobase sequences of the one or more pairs of complementary binding domains.
A method of making a single-stranded tile (SST) structure, comprising:
- mixing one or more single-stranded gamma peptide-nucleic acid (ss-γPNA) species in a solvent for the ss-γPNA;
- and
- complexing the one or more ss-γPNA species in the solvent to form an ordered complex of the one or more single-stranded gamma peptide-nucleic acids (ss-γPNAs),
- wherein the ss-γPNA species comprising one or more pairs of complementary binding domains comprising complementary nucleobase sequences arranged on the one or more ss-γPNA species to produce a periodic arrangement of at least 3 molecules of the one or more ss-γPNA species by hybridization of the complementary nucleobase sequences to produce the SST structure.
Dependencies are inferred from the claim text.