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US 12,297,219 B2Granted
Phosphorodiamidate morpholino oligomers
AssigneeSarepta Therapeutics, Inc.
InventorsBaozhong Cai, Mitchell Martini, Katie Thomas, Ross Shimabuku
Life of this patent
Estimating the term…
Abstract
Provided herein are processes for preparing an oligomer (e.g., a morpholino oligomer). The synthetic processes described herein may be advantageous to scaling up oligomer synthesis while maintaining overall yield and purity of a synthesized oligomer.
Claims2
A compound of Formula (X):
- or a pharmaceutically acceptable salt thereof, wherein
- R1 is a support-medium, and
- R2 is, independently at each occurrence, selected from the group consisting of:
- and
- wherein R2 is at each position from 1 to 25 and 5′ to 3′:
- Position No. 5′ to 3′
- R2
- 1
- DPG
- 2
- T
- 3
- T
- 4
- DPG
- 5
- PC
- 6
- PC
- 7
- T
- 8
- PC
- 9
- PC
- 10
- DPG
- 11
- DPG
- 12
- T
- 13
- T
- 14
- PC
- 15
- T
- 16
- DPG
- 17
- PA
- 18
- PA
- 19
- DPG
- 20
- DPG
- 21
- T
- 22
- DPG
- 23
- T
- 24
- T
- 25
- PC.
54 more elements
Dependencies are inferred from the claim text.