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US 12,297,213 B2Granted
Metal hydroxide complex comprising modified multilayer hydroxide structure comprising active ingredient and method of manufacturing same
AssigneesCnpharm Co., Ltd., Hyundai Bioscience Co., Ltd.
InventorsHo-Jun Kim, Ki-Yeok Kim
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Abstract
The present invention relates to a metal hydroxide complex including the multilayer hydroxide structure of Chemical Formula 1, including a base layer, a surface layer and an active ingredient, a metal hydroxide complex manufactured by subjecting an active ingredient and a metal hydroxide structure precursor to coprecipitation through a precipitation reaction using an alcohol and water, and a method of manufacturing the same.
Claims13
A metal hydroxide complex comprising:
- a multilayer hydroxide structure of Chemical Formula I below, comprising a base layer, a surface layer and an active ingredient:
- {[Mx(OH)z]B[My(OH)w]S}{(An)q}·m(H2O) [Chemical Formula 1]
- wherein [Mx(OH)z]B represents the base layer of the multilayer hydroxide structure, and [My(OH)w]S represents the surface layer of the multilayer hydroxide structure,
- M is any one divalent metal cation selected from the group consisting of Zn2+,
- x is 0.6 to 3,
- y is more than 0 and up to 2,
- z is 1 to 5,
- w is more than 0 and up to 4,
- z+w is 1 to 9,
- q is 1 to 4,
- mis 0.1 to 10,
- n is a charge number of A, and
- the active ingredient is represented by A, in which A is an anionic compound comprising ascorbic acid,
- wherein the multilayer hydroxide structure has a powder-X-ray diffraction pattern having peak values of diffraction angles (2θ) of 5.96±1°, 33.46±1 and 59.3±1°.
11 more elements
A metal hydroxide complex comprising:
- a multilayer hydroxide structure of Chemical Formula I below, comprising a base layer, a surface layer and an active ingredient:
- {[Mx(OH)z]B[My(OH)w]S}{(An)q}·m(H2O) [Chemical Formula 1]
- wherein [Mx(OH)z]B represents the base layer of the multilayer hydroxide structure, and [My(OH)w]S represents the surface layer of the multilayer hydroxide structure,
- M is any one divalent metal cation selected from the group consisting of Zn2+,
- x is 0.6 to 3,
- y is more than 0 and up to 2,
- z is 1 to 5,
- w is more than 0 and up to 4,
- z+w is 1 to 9,
- q is 1 to 4,
- mis 0.1 to 10,
- n is a charge number of A, and
- the active ingredient is represented by A, in which A is an anionic compound comprising ascorbic acid,
- wherein the multilayer hydroxide structure has a powder-X-ray diffraction pattern having peak values of diffraction angles (2θ) of 5.96±1°, 8.5±1, 10.36±1, 13.36±1°, 19±1, 20.84±1, 21.7±1, 26.34±1, 37.68±1, 31.48±1, 33.78±1, 34.88±1 and 59.3±1.
11 more elements
A metal hydroxide complex comprising:
- a multilayer hydroxide structure of Chemical Formula I below, comprising a base layer, a surface layer and an active ingredient:
- {[Mx(OH)z]B[My(OH)w]S}{(An)q}·m(H2O) [Chemical Formula 1]
- wherein [Mx(OH)z]B represents the base layer of the multilayer hydroxide structure, and [My(OH)w]S represents the surface layer of the multilayer hydroxide structure,
- M is any one divalent metal cation selected from the group consisting of Zn2+,
- x is 0.6 to 3,
- y is more than 0 and up to 2,
- z is 1 to 5,
- w is more than 0 and up to 4,
- z+w is 1 to 9,
- q is 1 to 4,
- mis 0.1 to 10,
- n is a charge number of A, and
- the active ingredient is represented by A, in which A is an anionic compound comprising ascorbic acid, wherein the multilayer hydroxide structure has a powder-X-ray diffraction pattern having peak values of diffraction angles (2θ) of 6.28±1°, 8.88±1°, 10.32±1, 13.42±1, 21.04±1, 28.14±1, 33.5±1 and 59.16±1°.
10 more elements
Dependencies are inferred from the claim text.