Modulators of STING (stimulator of interferon genes)

A compound of formula (I):

• or a pharmaceutically acceptable salt thereof, wherein
• each
• in a ring independently represents two conjugated double bonds in a five-membered heteroaromatic ring and three conjugated double bonds in a six-membered aromatic or heteroaromatic ring;
• W1 is selected from CR11 and N;
• X1 is selected from CR1, N, NR1, O and S;
• X2 is selected from CR2, N, NR2, O and S;
• X3 is selected from CR3, N, NR3, O and S;
• where two or three of X1, X2 and X3 are independently selected from N, NR1, NR2, NR3, O and S;
• and
• where at least one of X1, X2 and X3 is selected from N, NR1, NR2 and NR3;
• Y1 is selected from N, NR4, O, S, and CR4;
• Y2 is selected from N, NR5, O, S, and CR5;
• Y3 is selected from N, NR6, O, S, and CR6;
• Y4 is selected from C and N;
• Y5 is selected from C and N;
• where at least one and not more than two of Y1, Y2 and Y3 are independently selected from N, NR4, NR5 and NR6;
• where when one of Y4 or Y5 is N, the other one of Y4 or Y5 is C;
• Z1 is selected from C and N;
• Z2 is selected from N, NR8 and CR8;
• Z3 is selected from N, NR9 and CR9;
• Z4 is selected from N, NR10 and CR10;
• Z5 is selected from N, NR7 and CR7;
• where two or three of Z1, Z2, Z3, Z4 and Z5 are independently selected from N, NR7, NR8, NR9, and NR10;
• each R1 is independently selected from the group consisting of H, C1-C8 alkyl, C1-C8 alkylene-NRR and C1-C8 alkylene-C(O) OR;
• each R2 is independently selected from the group consisting of H, C1-C8 alkyl, C1-C8 alkylene-NRR, C1-C8 alkylene-C(O) OR, C1-C8 alkylene-OR and C1-C8 alkylene-O—P(O)(OH)2;
• each R3 is independently selected from the group consisting of H, C1-C8 alkyl, C1-C8 alkylene-NRR, C1-C8 alkylene-C(O) OR and C1-C8 alkylene-O—P(O)(OH)2;
• each R4 is independently selected from the group consisting of H, —OR, —NRR, C1-C8 alkyl optionally substituted with one or two —OR, C1-C8 alkylene-NRR, —C(O) OR, C1-C8 alkylene-C(O) OR, 3-10 membered heterocycle, C1-C8 alkylene-3-10 membered heterocycle optionally substituted with one 3-10 membered heterocycle, (C3-C10)-cycloalkyl, and C1-C8 alkylene-(C3-C10)-cycloalkyl;
• each R5 is independently selected from the group consisting of H, —OR, C1-C8 alkyl, —NRR, C1-C8 alkylene-NRR, —C(O) OR, C1-C8 alkylene-C(O) OR, 3-10 membered heterocycle, C1-C8 alkylene-3-10 membered heterocycle optionally substituted with one 3-10 membered heterocycle, and C1-C8 alkylene-OR;
• each R6 is H;
• R7 is selected from the group consisting of H, halo, hydroxy and NH2;
• R8 is selected from the group consisting of H, C1-C8 alkyl optionally substituted with one or two —NRR or —OR, C1-C8 alkylene-C(O) OR and C1-C8 alkylene-SO2R;
• R9 is H;
• R10 is selected from the group consisting of H, C1-C8 alkyl optionally substituted with one or two —OR, and halo;
• R11 is selected from the group consisting of H, C1-C8 alkyl, —OR and halo;
• R12 is —C(O)N(R)2;
• R13 is H;
• each R is independently selected from the group consisting of H, C1-C8 alkyl, and C1-C8 haloalkyl, or two R join to form, together with the N atom to which they are bound, a 3-10 membered heterocycle, where said 3-10 member heterocycle contains one N and optionally one or two additional heteroatoms each independently selected from N, O and S;
• and
• where, when two R join to form, together with the atom or atoms to which they are bound, a 3-10 membered heterocycle, said 3-10 membered heterocycle is optionally substituted with one or more substituents each independently selected from C1-C8 alkyl, hydroxy, C1-C8 alkoxy, —(C3-C10) cycloalkyl, 3-10 membered heterocycle, halo and cyano.