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US 12,297,173 B2Granted
Compounds and methods for inhibiting CYP26 enzymes
AssigneeQueen's University at Kingston
InventorsDonald Andrew Cameron, Martin Petkovich, Uttam Saha
Life of this patent
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Abstract
Compounds that are inhibitors of retinoic acid inducible P450 (CYP26) enzymes. The compounds have retinoid activity, are resistant to CYP26-mediated catabolism, act as inhibitors of CYP26B1, and are used for treating diseases that are responsive to retinoids.
Claims12
A method of treating a disease or condition of the eye in a mammal, the method comprising administering to a mammal in need thereof a compound of the following formula:
- wherein the administering is sufficient for treating the disease or condition of the eye in the mammal, and wherein the disease or condition of the eye is selected from the group consisting of proliferative vitreoretinopathy (PVR), retinal detachment, and dry eye.
Dependencies are inferred from the claim text.