Compounds useful for treating liver diseases
AssigneeAbionyx Pharma SA
InventorJean-Louis Henri Dasseux
Life of this patent
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Abstract
This invention provides compounds, for example, of Formulae (A)-(H) and (J)-(AA) and pharmaceutically acceptable salts, solvates, esters, amides, and prodrugs thereof. The invention further provides pharmaceutical compositions comprising a compound of the invention, and a pharmaceutically acceptable carrier or vehicle. The compounds and compositions disclosed herein are useful for treating or preventing various diseases and conditions, for example liver disease such as liver fibrosis, fatty liver disease, non-alcoholic fatty liver disease (NAFLD) or non-alcoholic steatohepatitis (NASH), and kidney diseases such as acute kidney injury (AKI).
Claims20
A compound of Formula (A):
- or a pharmaceutically acceptable salt, solvate, ester, amide, or prodrug thereof, wherein:
- each of R1 and R2 is independently —C1_C6 alkyl, —C2_C6 alkenyl, —C2_C6 alkynyl, phenyl, or benzyl;
- or alternatively, R1 and R2 together with the carbon atom to which R1 and R2 are attached form a C3_C7 cycloalkyl group;
- X is —CH2OH, —COOH, —COH, —COOR3, —COOCH2CONR4R5, —SO3H,
- R3 is —C1_C6 alkyl, —C2_C6 alkenyl, —C2_C6 alkynyl, phenyl, or benzyl;
- each of R4 and R5 is independently alkyl, aryl, or heteroaryl;
- or alternatively, R4 and R5 together with the carbon atom to which R4 and R5 are attached form a heterocycle;
- each of R6 and R7 is independently H, —C1_C6 alkyl, —C2_C6 alkenyl, or —C2_C6 alkynyl;
- and
- n is 0, 1, 2, 3, or 4.
A compound having the structure:
- or a pharmaceutically acceptable salt, solvate, ester, amide, or prodrug thereof.
A compound having the structure:
- or a pharmaceutically acceptable salt, solvate, ester, amide, or prodrug thereof.
Dependencies are inferred from the claim text.