Glycerol derivative, preparation method therefor, and immunomodulator comprising same as effective ingredient
AssigneeEnzychem Lifesciences Corporation
InventorsKi Young Sohn, Jae Wha Kim, Sun Young Yoon, Chang Hyun Yoo, Jin Seon Jeong
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Abstract
Disclosed are a glycerol derivative that is useful for improving, preventing or treating inflammation-related diseases by inhibiting overexpression of various inflammatory cytokines such as IL-4, IL-6 and so on, or chemokine CXCL8 and reducing migration of HL-60 cell lines, preparation method therefor, and an immunomodulator containing the same as active ingredient. It includes a glycerol derivative represented by Chemical formula 2 or 3 in the specification.
Claims2
A glycerol derivative represented by the following Chemical formula 3,
- in Chemical formula 3, R6 and R7 are independently palmitoyl or linoleoyl, and R8 is —OR9 or —NHR9 (wherein, R9 is ethyl).
A method for inhibiting or reducing an immune response by inhibiting overexpression of one or more inflammatory cytokines selected from the group consisting of IL-4, IL-6, and CXCL8 comprising a step of administering an effective amount of a glycerol derivative represented by the following Chemical formula 3 as an active ingredient to a subject in need thereof,
- in Chemical formula 3, R6 and R7 are independently a fatty acid group having 2 to 18 carbon atoms, and R8 is —OR9 or —NHR9 (wherein, Ry is an alkyl group having 1 to 3 carbon atoms).
Dependencies are inferred from the claim text.