Back to results
US 12,297,157 B2Granted
18F-labeled peptide ligands useful in PET and Cerenkov luminescene imaging
AssigneeCornell University
InventorJohn W. Babich
Life of this patent
Estimating the term…
Abstract
The present technology is directed to compounds, intermediates thereof, compositions thereof, medicaments thereof, and methods related to the imaging of mammalian tissue via 18F-labeled peptide ligands disclosed herein.
Claims3
A compound that is a 18F-labeled somatostatin receptor agonist according to Formula I
- or a pharmaceutically acceptable salt and/or solvate thereof, wherein
- Z10, Z11, and Z12 are each independently OH;
- W4 is H;
- one of W2 and W3 is
- or one of Y2 and Y3 is
- and the remaining W2 and W3 is H and the remaining Y2 and Y3 is OH or NH2;
- wherein T2 is —C(O)— or —C(O)NH—, one of R7, R8, and R9 and one of R10, R11, and R12 is
- and the remaining two of R7, R8, and R9 are each H and the remaining two of R10, R11, and R12 are each H;
- X2 is absent, O, S, or NH;
- m′ and a′ are each independently 0, 1, 2, or 3;
- n is 0 or 1;
- p′ is 0, 1, 2, or 3, provided that when p′ is 0 then X2 is absent;
- q′ is 1 or 2;
- x′ is 0, 1, 2, or 3;
- and
- y′ is 1 or 2.
13 more elements
Dependencies are inferred from the claim text.